欢迎访问沈阳真空杂志社 Email Alert    RSS服务

VACUUM ›› 2026, Vol. 63 ›› Issue (2): 90-96.doi: 10.13385/j.cnki.vacuum.2026.02.13

• Measurement and Control • Previous Articles     Next Articles

Research on Fuzzy PID Freeze Dryer Vacuum Control System Based on Intelligent Optimization

ZOU Hongwu, HE Chengjie, GUO Chenghu, JU Peng   

  1. Shinva Medical Instrument Co., Ltd., Zibo 255086, China
  • Received:2025-04-30 Online:2026-03-25 Published:2026-03-27

Abstract: Due to the nonlinear and time-varying characteristics of traditional freeze-drying machine vacuum systems, conventional PID control algorithms cannot meet the requirements for high-precision vacuum control. To improve the vacuum control performance of the freeze-drying machine, its vacuum system was optimized and designed using an intelligent optimized fuzzy PID controller. The input domain of the fuzzy controller was optimized and adjusted through the ABC algorithm. Meanwhile, the output of the controller was corrected based on the characteristics of the valve-controlled vacuum, effectively suppressing the nonlinear and time-varying effects of the system and improving the dynamic performance of the vacuum control. The actual testing data show that the vacuum control performance of the freeze-drying machine with the new system is better than that of conventional PID and fuzzy PID control systems in terms of adjustment time, overshoot, and steady-state error. This intelligent vacuum control system can effectively improve the control capability of the vacuum inside the freeze-drying machine during the freeze-drying process, thereby ensuring the accurate and smooth completion of the freeze-drying process.

Key words: freeze dry, vacuum control, fuzzy PID, ABC algorithm

CLC Number:  TP273+.4;S226.6

[1] 邱勋荣, 李玉姗, 万琴, 等. 真空冷冻干燥对中药材质量的影响与调控技术研究进展[J]. 中草药, 2024, 55(4): 1377-1388.
[2] JAKUBOWSKA E, BIELEJEWSKI M, MILANOWSKI B, et al.Freeze-drying of drug nanosuspension- study of formulation and processing factors for the optimization and characterization of redispersible cilostazol nanocrystals[J]. Journal of Drug Delivery Science and Technology, 2022, 74: 103528.
[3] 张哲, 张智弘, 张靖含, 等. 玉米种子真空冷冻干燥微观实验研究及模型分析[J]. 包装工程, 2024, 45(3): 72-80.
[4] 李一喆. 橘皮油微胶囊制备及其理化性质研究[D]. 大连: 大连理工大学, 2020.
[5] 郭彦伟, 李保国, 郭柏松, 等. LY0型冻干机冻干箱内压力场模拟分析[J]. 流体机械, 2014, 42(3): 57-61.
[6] KAMENIK B, HRIBERŠEK M, ZADRAVEC M. Simulation of ice deposition in a freeze dryer condenser: a computational fluid dynamics study[J]. Applied Thermal Engineering, 2024, 247: 123019.
[7] 厉建国, 万金庆, 赵彦峰. 冰温真空干燥系统的设计与实现[J]. 食品与机械, 2017, 33(11): 89-91,156.
[8] PIECHNIK E,PALACZ M, TOLSTOREBROV I, et al.Design and evaluation of an R290-based freezing system and air distribution in a domestic-scale microwave-heated freeze-dryer prototype[J]. Innovative Food Science and Emerging Technologies, 2024, 96: 103781.
[9] 徐言生, 李玉春, 何钦波, 等. 大型食品真空冷冻干燥设备控制系统设计与应用研究[J]. 真空科学与技术学报, 2008, 28(4): 383-387.
[10] ZHU M, YAND C L, LI W L.Autotuning algorithm of particle swarm PID parameter based on D-Tent chaotic model[J]. Journal of Systems Engineering and Electronics, 2013, 24(5): 828-837.
[11] 乔健, 罗磊, 托乎提努尔, 等. 基于模糊PID的真空蝶阀压力控制算法研究[J]. 真空科学与技术学报, 2025, 45(1): 73-79.
[12] HAN X D, LI G, XU M H, et al.Miniature capacitance diaphragm gauge for absolute vacuum measurement[J]. Measurement, 2022, 194: 110851.
[13] 秦璐璐, 高乔枫, 张帅, 等. 一种非线性皮拉尼真空变送器校准方法的研究[J]. 真空, 2025, 62(3): 65-69.
[14] CHEN S, FENG L H D, GUO S, et al. A composite-type MEMS pirani gauge for wide range and high accuracy[J]. Sensors, 2023, 23(3): 1276.
[15] 吴俊, 吴杰, 干蜀毅, 等. 干式螺杆真空泵的理论研究进展[J]. 真空, 2024, 61(5): 36-45.
[16] 姜燮昌, 刘吉峰, 高波. 关于制药行业真空干燥工艺过程的参数控制与真空机组的选型及计算[J]. 真空, 2016, 53(2): 49-52.
[17] 张世伟, 高雷鸣, 李润达, 等. 罗茨真空机组预抽阶段的抽气特性比较研究[J]. 真空, 2022, 59(1): 1-6.
[18] LIU H, ZHAO B, WANG B, et al.Flow control characteristics of the digital and mechanical redundancy control electric modulation valve[J]. Journal of Zhejiang University-SCIENCE A, 2022, 23(8): 599-609.
[19] 许丽, 吴泽明, 刘旭, 等. 模糊神经网络锅炉温度控制系统[J]. 真空, 2021, 58(4): 77-80.
[20] RINKEVICIENE R, MITKIENE B.Design and analysis models with PID and PID fuzzy controllers for six-phase drive[J]. World Electric Vehicle Journal, 2024, 15(4):164.
[21] WANG L, ZHAO Y J, WAND Y F, et al.A high-accuracy decoupling balance control method for an auto-balancing bridge based on a variable-domain fuzzy-PID controller[J]. Symmetry, 2025, 17(3): 354.
[22] ZYCH M, DYJA R, GAWRONSKA E, et al.Optimization of the temperature fields using the ABC algorithm by selecting the kappa parameter in heat conduction[J]. Acta Physica Polonica: A, 2024, 146(6): 826-829.
[23] 吴文进, 吴晶, 郭海婷, 等. 基于变论域模糊PID算法的锂电池组级联式均衡控制[J]. 电子测量与仪器学报, 2024, 38(8), 137-144.
[24] 赵玉玺, 胡军, 刘昶希, 等. 基于ABC-PID 算法的变量喷雾控制系统设计与试验[J]. 农机化研究, 2024, 46(7): 57-63.
[25] HEO D H, SHIN G I, LEE B H.A simplified fuzzy PID control for nonlinear characteristics of heated glass[J]. Journal of Electrical Engineering and Technology, 2025, 20(4): 2357-2364.
[26] 李嘉, 张良俊, 吴仕泽, 等. 基于模糊PID的低温环境试验系统控制特性研究[J]. 真空与低温, 2023, 29(2): 180-187.
[27] 何宇驰, 陈永乐, 贺良, 等. 基于STM32的茶叶揉捻机揉捻桶转速模糊PID设计[J]. 食品与机械, 2024, 40(7): 74-80.
[28] 浦晨玮, 罗辉, 吴洁, 等. 变泄漏容腔内气体的高精度恒压控制[J]. 国防科技大学学报, 2024, 46(5): 110-120.
[29] MOHINDRU P.Review on PID, fuzzy and hybrid fuzzy PID controllers for controlling non-linear dynamic behaviour of chemical plants[J]. Artificial Intelligence Review, 2024, 57(4): 97.
[30] 刘丽萍. 基于Fuzzy算法的枸杞冻干系统设计[J]. 农机化研究, 2012, 34(10): 103-106.
[1] CHEN Changjie, LUO Chun. Investigation on Developing the Freeze-Dryer for Processing Products with Low Triple Point Temperature [J]. VACUUM, 2025, 62(1): 57-61.
[2] YANG Jie, PENG Run-ling, GUO Jun-de, WANG Peng, YIN Sha-sha. Recent Development of Spray Freeze Drying Technology and Equipment [J]. VACUUM, 2022, 59(2): 72-80.
[3] PENG Run-ling, WEI Yan, WANG Peng, YANG Jie, WU Ya-mei. Study on Vacuum Freeze Drying Technology and Efficiency of Kiwifruit Slices [J]. VACUUM, 2021, 58(6): 79-85.
[4] PENG Run-ling, YIN Sha-sha, WEI Yan, LIU De-rong, WANG Ning. Preparation of Inorganic Nanopowders by Vacuum Freeze-drying [J]. VACUUM, 2019, 56(5): 77-84.
[5] YIN Sha-sha, PENG Run-ling, WEI Yan, CAO Wei, WANG Ning. Preparation of nano-MoS2 powders by vacuum freeze-drying [J]. VACUUM, 2018, 55(6): 80-83.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] LI Min-jiu, XIONG Tao, JIANG Ya-lan, HE Yan-bin, CHEN Qing-chuan. 20kV high voltage based on double transistor forward converter pulse power supply for metal deburring[J]. VACUUM, 2018, 55(5): 19 -24 .
[2] LIU Yan-wen, MENG Xian-zhan, TIAN Hong, LI Fen, SHI Wen-qi, ZHU Hong, GU Bing. Test of ultra high vacuum in space traveling-wave tube[J]. VACUUM, 2018, 55(5): 25 -28 .
[3] HUANG Si, WANG Xue-qian, MO Yu-shi, ZHANG Zhan-fa, YING Bing. Experimental study on similarity law of liquid ring compressor performances[J]. VACUUM, 2018, 55(5): 42 -45 .
[4] WEI Jun、, LIU Zhi-hong, LI Bo, CHEN Xiao-li. Brazing and vacuum leak detection of large caliber alumina ceramic and stainless steel[J]. VACUUM, 2018, 55(5): 62 -65 .
[5] ZHAO Yan-hui, SHI Wen-bo, LIU Zhong-hai, LIU Zhan-qi, YU Bao-hai. Effect of deposition process parameters on arc ion plating[J]. VACUUM, 2018, 55(6): 49 -59 .
[6] ZHANG Fen-li, DENG Jing-lian, WANG Jie-feng, MENG Qing-yuan. Study on the pretreatment cleaning process of steel tube before coating[J]. VACUUM, 2018, 55(6): 60 -63 .
[7] DUAN Yong-li, Deng Wen-yu, QI Li-jun, LIU Kun, SUN Bao-yu, WANG Qing. Influence of Tb grain boundary diffusion on the magnetic performance and heat resistance of sintered NdFeB magnet[J]. VACUUM, 2018, 55(6): 76 -79 .
[8] XU Jun-qi, LI Hou-jun, LI Mian, WANG Jian, SU Jun-hong, GOLOSOV Dmitriy A.. Optical and laser damage characteristics of TiO2 films prepared by thermal evaporation deposition technique[J]. VACUUM, 2019, 56(1): 39 -44 .
[9] WANG Chun-ming, ZHANG Ming-da, SU Yu-ping. Discussion on leak detection method of vacuum application equipment[J]. VACUUM, 2019, 56(1): 52 -55 .
[10] ZHU Lei, LI Jing. Harm and prevent measures for chamber pollution of gas quenching furnace[J]. VACUUM, 2019, 56(1): 59 -62 .