欢迎访问沈阳真空杂志社 Email Alert    RSS服务

VACUUM ›› 2020, Vol. 57 ›› Issue (6): 64-68.doi: 10.13385/j.cnki.vacuum.2020.06.14

• Vacuum Acquisition System • Previous Articles     Next Articles

Vacuum System for Boron Neutron Capture Therapy(BNCT)

LIU Shun-ming1, 2, OUYANG Hua-fu1, 2, HU Zhi-liang1, 2, SONG Hong1, 2, HUANG Tao1, 2, WANG Peng-cheng1, 2, LIU Jia-ming1, 2, GUAN Yu-hui1, 2, TAN Biao1, 2, LIU Sheng-jin1, 2, XIAO Yong-chuan1, 2, CAO Xiu-xia1, 2, LU Yong-jia1, 2, XUE Kang-jia1, 2, WU Xuan1, 2, KANG Ming-tao1, 2, BNCT Team1, 2   

  1. 1.Spallation Neutron Source Science Center, Dongguan 523808 China;
    2.Institute of High Energy Physics, Chinese Academy of Sciences(CAS), Beijing 100049 China;
  • Received:2020-07-16 Online:2020-11-25 Published:2020-11-30

Abstract: The boron neutron capture therapy(BNCT) device consists of an ECR ion source, a low energy transmission line(LEBT), a 3.5 MeV radio frequency quadrupole accelerator(RFQ), a high energy transmission line(HEBT)and a target station. The article first introduces the composition of the BNCT vacuum system, compares the differences between the BNCT and CSNS ion source vacuum systems, and gives the HEBT vacuum system design scheme and gas production calculation method. Using the Molflow software, the static pressure distribution of the HEBT vacuum system and the dynamic pressure distribution during beam bombardment are calculated and compared with the current vacuum state.

Key words: boron neutron capture therapy, vacuum system composition, high energy transmission line, Molflow, pressure distribution

CLC Number: 

  • TL53
[1] 赵志祥. 应用前景广阔的硼中子俘获治疗技术[J]. 中国核工业, 2013, (9): 33-35.
[2] Hatanaka H, Nakagawa Y.Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy[J]. Int. J. Radiat. Oncol. Biol. Phys. 1994, 28(5): 1061-1066.
[3] Jeffrey A C, Terry M B, Peggy L M, et al.Neutron capture therapy of the 9lrat gliosarcoma using the P-boronophenylalanine-fructose complex[J]. International Journal of Radiation Oncology Biology Physics, 1994, 30(3): 643-652.
[4] 江海燕, 储德林. 硼中子俘获治癌的技术进展及关键问题[J]. 物理通报, 2014(4): 114-116.
[5] Nomoto T.对-硼烷苯丙氨酸与聚乙烯醇结合增强杀伤癌细胞效果[J]. 生物医学工程与临床, 2020, 24(2): 232.
[6] Blue T E, Yanch J C.Accelerator-based epithermal neutron sources for boron neutron capture therapy of brain tumors[J]. Journal of Neuro-Oncology, 2003, 62(1): 19-31.
[7] Green S.Developments in accelerator based boron neutron capture therapy[J]. Radiation Physics & Chemistry, 1998, 51(4-6): 561-569.
[8] 欧阳华甫, 肖永川, 刘盛进, 等. BNCT加速器设计和调试[J]. 白城师范学院学报, 2020, 34(2): 1-9.
[9] 董海义, 宋洪, 李琦, 等. 中国散裂中子源(CSNS)真空系统研制[J]. 真空, 2015, 52(4): 1-6.
[10] 马应林, 王庆斌, 王宇飞, 等. 一种硼中子俘获治疗装置的辐射安全联锁系统设计[J]. 核安全, 2018, 17(6): 87-92.
[11] 王鹏程, 黄涛, 刘佳明, 等. 中国散裂中子源(CSNS)LRBT输运线真空系统[J]. 真空, 2019, 56(5): 21-25.
[12] 达道安. 真空设计手册[M]. 国防工业出版社, 2004: 112-121.
[13] Sato T, Niita K, Matsuda N, et al.Particle and heavy ion transport code system, PHITS, version 2. 52[J]. Journal of Nuclear Science & Technology, 2013, 50(9): 913-923.
[14] Kersevan R.Analytical and Numerical Tools for VacuumSystems[J]. CAS CERN Accelerator School, Vacuum inAccelerators: Platja D′Aro, Spain, 2006, (3): 285
[15] 郎嘉琪, 谢远来, 胡纯栋, NBI团队. 中性束注入器真空系统差分抽气性能优化研究[J]. 真空科学与技术学报, 2020, 40(2): 113-118.
[16] 崔遂先, 谈治信, 刘玉魁. 真空技术常用数据表[M]. 北京: 化学工业出版社, 2012: 147-153.
[1] HU Chun-dong, LANG Jia-qi, XIE Yuan-lai, WANG Ming-xiang, ZHANG Zhao-yuan, NBI Team. Simulation of Gas Temperature Distribution in Cryo-Vacuum Space for a Neutral Beam Injector [J]. VACUUM, 2020, 57(5): 75-78.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
辽ICP备06004570号-4
Copyright © VACUUM, All Rights Reserved.
Tel: （024）24134406 24110136 24121929　Fax: （024） 24121929　E-mail: zkzk1964@126.com
Powered by Beijing Magtech Co. Ltd