Abstract: This article briefly introduces the basic principles of relativity and quantum mechanics, which cites the recent scientific news to discuss the application and usage of vacuum science and technology in these fields. As we know(everyone knows, including the content that does not appear in the books), as the mother of the universe, vacuum is bigger and older than the universe. Moreover,vacuum is the physical environment of relativity and quantum mechanics. Vacuum science and technology is an essential theory for the study of relativity and quantum mechanics. The morden physics is on the eve of a great revolution. The research problems of black holes, dark matter, dark energy, gravitational waves and the origin of particles have put forward serious challenges to physics. Perhaps physics can gain ground from studying scientific problems or resolving the contradictions between relativity and quantum mechanics. This article is divided into three parts: (1) The recent progress of relativity and vacuum technology; (2) Previous ideology frames were sorted out; (3) The relevant knowledge of quantum mechanics and zero point energy.

Key words: relativity, quantum mechanics, vacuum science and technology