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真空 ›› 2022, Vol. 59 ›› Issue (2): 72-80.doi: 10.13385/j.cnki.vacuum.2022.02.14

• 真空应用 • 上一篇    下一篇

喷雾冷冻干燥技术与设备发展现状*

杨杰, 彭润玲, 郭俊德, 王鹏, 尹沙沙   

  1. 西安工业大学机电工程学院,陕西 西安 710021
  • 收稿日期:2020-12-08 出版日期:2022-03-25 发布日期:2022-04-14
  • 通讯作者: 彭润玲,副教授。
  • 作者简介:杨杰(1996-),男,河南省安阳市人,硕士生。
  • 基金资助:
    *陕西省教育厅专项科研计划项目(20JK0668)

Recent Development of Spray Freeze Drying Technology and Equipment

YANG Jie, PENG Run-ling, GUO Jun-de, WANG Peng, YIN Sha-sha   

  1. School of Mechanical Engineering, Xi′an Technological University, Xi′an 710021, China
  • Received:2020-12-08 Online:2022-03-25 Published:2022-04-14

摘要: 喷雾冷冻干燥技术近几年发展较快,在食品、医药、材料等领域都有广泛的应用,但是相应的喷雾冷冻干燥设备却发展较慢,在一定程度上限制了喷雾冷冻干燥技术的发展。本文首先介绍了喷雾冷冻干燥技术的原理与特点,及其应用现状,然后重点介绍了喷雾冷冻干燥设备的现状,分析了现有的各类喷雾冷冻干燥设备的优势和不足之处,并总结了近几年典型的喷雾冷冻干燥过程数学模型,探讨了喷雾冷冻干燥技术目前存在的问题和今后的发展方向。

关键词: 喷雾冷冻干燥, 设备, 喷雾冻结过程, 数学模型

Abstract: Spray freeze-drying technology has developed rapidly in recent years, which has been widely applied in food, medicine, materials and other fields. However, the corresponding spray freeze drying equipment has developed slowly, which limits the development of spray freeze drying technology to a certain extent. This paper first introduces the principle and characteristics of spray freeze drying technology. Then it introduces the current situation of spray freeze drying equipment,analyzes the advantages and disadvantages of the existing spray freeze drying equipment, summarizes the typical mathematical models of spray freeze drying process in recent years, and probes into the existing problems and future development directions of spray freeze drying technology.

Key words: spray freeze drying, equipment, spray freezing process, mathematical model

中图分类号: 

  • TQ028.6
[1] 耿县如, 徐庆, 李占勇,等. 喷雾冷冻法单个液滴冻结过程模拟[J]. 化工进展, 2012(5): 34-39.
[2] WANNING S, SÜVERKRÜP R, LAMPRECHT A. Jet-vortex spray freeze drying for the production of inhalable lyophilisate powders[J]. European Journal of Pharmaceutical Sciences, 2016, 96: 1-7.
[3] PATTON J S.Mechanisms of macromolecule absorption by the lungs[J]. Adv Drug Deliv Rev, 1996, 19(1): 3-36.
[4] MARQUEZ L, DE ABREU F A M, FERREIRA C L, et al. Enhanced bone healing of rat tooth sockets after administration of epidermal growth factor (EGF) carried by liposome[J]. Injury, 2013, 44(4): 558-564.
[5] YIN F, GUO S, GAN Y, et al.Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor[J]. International Journal of Nanomedicine, 2014, 2014: 1665-1676.
[6] SCHIFFTER H, CONDLIFFE J, VONHOFF S.Spray-freeze drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery[J]. Journal of the Royal Society Interface, 2010, 7:483-500.
[7] ZHANG S, LEI H, GAO X, et al.Fabrication of uniform enzyme-immobilized carbohydrate microparticles with high enzymatic activity and stability via spray drying and spray freeze drying[J]. Powder Technology, 2018, 330: 40-49.
[8] HER J Y, SONG C S, LEE S J, et al.Preparation of kanamycin powder by an optimized spray freeze-drying method[J]. Powder Technology, 2010, 199(2): 159-164.
[9] POURSINA N, VATANARA A, ROUINI M R, et al.The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process[J]. Acta Pharmaceutica, 2016, 66(2): 207-218.
[10] ISHWARYA S P, ANANDHARAMAKRISHNAN C, STAPLEY A G F. Spray-freeze-drying: A novel process for the drying of foods and bioproducts[J]. Trends in Food Science & Technology, 2015, 41(2):161-181.
[11] ZHANG F, MA X Y, WU X S, et al.Inert particles as process aid in spray-freeze drying[J]. Drying Technology, 2019, 38(1-2): 71-79.
[12] 张子琪, 王锋, 李清明, 等. 干制方式对紫淮山全粉的物理特性及其抗氧化能力的影响[J]. 食品研究与开发, 2018, 39(19): 26-31.
[13] DOLLY P, ANISHAPARVIN A, JOSEPH G S, et al.Microencapsulation of lactobacillus plantarum (mtcc 5422) by spray-freeze-drying method and evaluation of survival in simulated gastrointestinal conditions[J]. Journal of Microencapsulation, 2011, 28(6): 568-574
[14] 车馨子, 段续, 王月月, 等. 喷雾冷冻干燥制备鱼油微胶囊[J]. 食品与机械, 2019, 35(7): 193-198+209.
[15] 曹琳, 邢亚阁, 苏菲烟, 等. 真空冷冻喷雾干燥下川藏高原冰酒发酵菌剂复合保护剂的配方优化[J]. 食品工业科技, 2018, 39(4): 88-93
[16] 徐祥阳, 席晓丽, 聂祚仁,等. 冷冻干燥法制备纳米Al2O3包覆W复合粉体[J]. 粉末冶金技术, 2010, 28(5): 355-360.
[17] ZHECHEVA E, MLADENOV M, ZLATILOVA P, et al.Particle size distribution and electrochemical properties of LiFePO4 prepared by a freeze-drying method[J]. Journal of the Physics and Chemistry of Solids, 2010, 71(5): 848-853.
[18] SU T, ZHANG P, WANG L, et al.Preparation of copper chromite by vaccum freezing drying method and its catalytic activity for sulfuric acid decomposition[J]. Chinese Journal of Chemistry, 2011, 28(12): 2339-2344.
[19] IMASHUKU S, UDA T, NOSE Y, et al.Fabrication and electrical characterization of 15% yttrium-doped barium zirconate-nitrate freeze drying method combined with vacuum heating[J]. Journal of Alloys & Compounds, 2011, 509(9): 3872-3879.
[20] MAZAN M O, MARRERO-JEREA J, SOLDATI ANALÍA, et al. Fe-doped ceria nanopowders synthesized by freeze-drying precursor method for electrocatalytic applications[J]. International Journal of Hydrogen Energy, 2015, 40(10):3981-3989.
[21] BOVONE G, KAWALE S, BERNINI C, et al.Freeze drying technique to prepare doped nanosized B powder[J]. Drying Technology, 2016, 34(8): 923-929.
[22] FUJITA Y, HIRA T, SHIDA K, et al.Microstructure of high battery-performance Li2FeSiO4/C composite powder synthesized by combining different carbon sources in spray-freezing/freeze-drying process[J]. Ceramics International, 2018, 44(10): 11211-11217.
[23] 刘宏, 桑元华, 秦海明, 等. 喷雾冷冻干燥法制备钕掺杂的钇铝石榴石微纳米粉体的方法: CN102173775A[P].2011-09-07.
[24] 陈敏, 唐泽勋, 商士波, 等. 一种喷雾冷冻干燥制备锂电负极材料钛酸锂的方法: CN106207150A[P].2016-12-07.
[25] LIU B, YOU Y, ZHANG H, et al.Synthesis of ZnO nano-powders via a novel PVA-assisted freeze-drying process[J]. Rsc Advances, 2016, 6(111): 1-25.
[26] BARICK P, SAHA B P, JOSHI S V, et al.Spray-freeze-dried nanosized silicon carbide containing granules: Properties, compaction behaviour and sintering[J]. Journal of the European Ceramic Society, 2016, 36(16):3863-3877.
[27] JIMÉNEZ-SAELICES C, SEANTIER B, CATHALA B, et al. Spray freeze-dried nanofibrillated cellulose aerogels with thermal superinsulating properties[J]. Carbohydrate Polymers, 2017, 157: 105-113.
[28] RAGHUPATHY B P C, BINNER J G P. Spray freeze drying of YSZ nanopowder[J]. Journal of Nanoparticle Research, 2012, 14(7):1-15.
[29] ALI M E, LAMPRECHT A.Spray freeze drying as an alternative technique for lyophilization of polymeric and lipid-based nanoparticles[J]. International Journal of Pharmaceutics, 2016, 516(1-2): 170-177.
[30] Kim H N, Kim J M, Kim M J, et al.Fabrication of transparent MgAl2O4 spinel via spray freeze drying of microfluidized slurry[J]. Ceramics International, 2017, 43(14): 11312-11317.
[31] HUANG B, QIAO Z, NIE F, et al.Fabrication of FOX-7 quasi-three-dimensional grids of one-dimensional nanostructures via a spray freeze-drying technique and size-dependence of thermal properties[J]. Journal of Hazardous Materials, 2010, 184(1-3): 561-566.
[32] 许莹, 王嘉新, 栾瀚森, 等. 喷雾冷冻干燥法制备布地奈德富马酸福莫特罗干粉吸入颗粒及其特性评价[J]. 中国医药工业杂志, 2019, 50(4): 422-429.
[33] 王珏, 朱壮志, 张晓红. 喷雾冷冻干燥技术及其在吸入制剂中的应用[J]. 中国医药工业杂志, 2018, 49(8): 65-72.
[34] WANG Z L, FINLAY W H, PEPPLER M S, et al.Powder formation by atmospheric spray-freeze-drying[J]. Powder Technology, 2006, 170(1): 45-52.
[35] SEBASTIÃO I B, ROBINSON T D, ALEXEENKO A. Atmospheric spray freeze-drying: Numerical modeling and comparison with experimental measurements[J]. Journal of Pharmaceutical Sciences, 2017,106(1): 1-10.
[36] 彭润玲, 肖明春, 刘德荣. 一种多功能干燥设备: 208124726U[P].2018-11-20.
[37] 佚名. 国内实验室用喷雾冷冻干燥机开发成功[J]. 食品与发酵工业, 2012, 38(3):48.
[38] 苏小军, 罗振海, 李雁含, 等. 紫淮山全粉喷雾冷冻干燥工艺及其特性研究[J]. 激光生物学报, 2018(4): 373-380.
[39] 吴铎, 张盛宇, 廖振锴, 等. 新型喷雾冷冻设备: CN205599104U[P].2016-09-28.
[40] 郑效东. 全自动密闭式喷雾冻干生产设备: CN205228009U[P].2016-05-11.
[41] 郑效东. 真空喷雾冷冻干燥设备: CN205228008U[P].2016-05-11.
[42] 王海鸥,江海涛,扶庆权,等. 一种连续式真空喷雾冷冻干燥设备: CN204739850U[P].2015-11-04.
[43] 苏伟光, 李胜, 傅宪辉, 等. 冷冻浓缩喷雾冷冻干燥装置及工艺: CN101745345A[P].2010-06-23.
[44] A·甘古利, F·W·德玛科, E·伦兹, 等. 使用带电介质加热的喷雾冷冻和搅拌干燥的散装冷冻干燥: CN107683398A[P].2018-02-09.
[45] 仓怀兴, 窦军, 唐勇, 等. 一种液氮喷雾冷冻造粒真空干燥装置和工作方法: CN106268503A[P].2017-01-04.
[46] 李梅青, 王星, 马玉玺. 一种喷雾冷冻升华干燥机: CN105664513A[P].2016-06-15.
[47] 李占勇, 徐庆, 吴中华, 等. 一种惰性粒子喷雾冷冻干燥设备及方法: CN102226629A[P].2011-10-26.
[48] ANDREW T, JONATHAN G M LEE B R, et al. Numerical analysis of in-flight freezing droplets: Application to novel particle engineering technology[J]. Food and Bioproducts Processing,2019, 116: 30-40.
[49] SEBASTIÃO I B, BHATNAGAR B, TCHESSALV S, et al. Bulk dynamic spray freeze-drying part 1: Modeling of droplet cooling and phase change[J]. Journal of Pharmaceutical Sciences, 2019, 108(6): 2063-2074.
[50] SEBASTIÃO I B, BHATNAGAR B, TCHESSALOV S, et al. Bulk dynamic spray freeze-drying part 2: Model-based parametric study for spray-freezing process characterization[J]. Journal of Pharmaceutical Sciences,2019,108(6): 2075-2085.
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